Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 7;13:167. doi: 10.1186/s12920-020-00817-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — General feature of the circRNAs identified in human heart. a The distribution of 20,214 circRNAs identified in human hearts from 5 normal (Nor1-5) and 5 DCM (DCM1-5) patients, was mapped in different chromosomes. The circos plot tracks represent the normalized expression (spliced reads per billion mapping, denoted as SRPBM) of circRNAs in the different samples. b Percentage of genomic origins of the identified circRNAs. c Schematic diagram showing that rt-circRNAs originate from SCAF8 (in red) and TIAM2 (in cyan) genes identified in human heart in this study (upper) and in studies by Werfel et al. (middle) [29] and Tan et al. [27] (bottom). Arrows point to the transcriptional directions of SCAF8 and TIAM2 genes. d Correlation between the expression of circRNAs and their host genes or randomly chosen linear genes. *p < 0.05. e The size distribution of identified circRNAs. f Distribution of circRNAs with respect to most upstream circularized exon. g Distribution of numbers of circRNAs produced per gene. h Four-set venn diagram showing the over-lapping circRNAs identified in human heart in this study and in studies by Tan et al., Werfel et al. and Van et al., as well as 263,738 non-redundant circRNAs obtained by merging human circRNAs in 4 circRNA databases including circBase (n = 91,986), circBank (n = 140,331), circRNADB (n = 32,883), and CIRCpedia V2 (n = 183,943). i Venn diagram showing the over-lapping circRNAs identified in human heart in this study and reported mouse and rat circRNAs. The 61,174 non-redundant mouse circRNAs were obtained by merging circRNAs reported by study of Werfel et al. (n = 9474), Jakobi et al. (n = 561), and Tan et al. (n = 2632), as well as 2 circRNA databases including circBase (n = 1756) and CIRCpedia V2 (n = 54,274). The 20,450 non-redundant rat circRNAs were obtained by merging circRNAs reported by study of Werfel et al. (n = 12,256) and CIRCpedia V2 (n = 17,083). j Venn diagram showing the number of circRNAs unique or common between normal and DCM human samples. k Number of human heart samples in which circRNAs with different abundance were identified