Table 2. Categorization of the NOTCH family members using identified clusters, per kingdom and phylum.
| Eukaryotes | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kingdoms | BACTERIA | Single Cell PROTISTS | ANIMALS | PLANTS | FUNGI | ||||||||||||
| Phylum | Perkinsozoa | Apicomplexa | Flagellates | Invertebrates | Chordates | ||||||||||||
| Placozoans | Cnidarians | Flatworms | Nematodes | Arthropods | Mammals | Fishes | Birds | Turtles | Amphibians | Lizards | |||||||
| NOTCH | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | – | – | – | – | – | ✓ | ✓ |
| 40 | 8 | 112 | 5 | 1 | |||||||||||||
| NOTCH1 | – | – | – | – | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | – |
| 152 | |||||||||||||||||
| NOTCH2 | – | – | – | – | ✓ | ✓ | – | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | – | ✓ |
| 114 | 1 | ||||||||||||||||
| NOTCH3 | – | – | – | – | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | ✓ | ✓ | ✓ | – | – |
| 83 | |||||||||||||||||
| NOTCH4 | – | – | – | – | – | ✓ | – | ✓ | ✓ | ✓ | – | – | ✓ | – | ✓ | – | – |
| 87 | |||||||||||||||||