Table 1. Effect of W.somnifera root extract on antioxidant enzyme activity in the cortex of control and sleep deprived rats.
Parameters | Normal control | Large platform control | Sleep Deprived rats | W. Somnifera treated Sleep deprived rats | P Value |
CAT | 29±1 | 18±2 a | 17 ±1a | 27 ± 1a,b,c | <0.0248 |
GPx | 44.5 ±5.5 | 36 ±4.a | 26± 2 a,b | 41 ±4 a,b,c | <0.0519 |
GR | 6.15± 0.55 | 4 ±0.2 a | 1.23± 0.26 a,b | 6.20 ±0.6 a,b,c | <0.0096 |
GSH | 11.50 ±0.50 | 9 ±0.80 | 6.4 ±0.36 a,b | 10.5 ± 0.07 a,b,c | <0.0212 |
GST | 66 ±4 | 55 ±5 | 46 ±4a | 62 ± 3 a,b,c | <0.0456 |
SOD | 42±3 | 31 ±1 | 23 ±1a,b | 42± 3.5 a,b,c | <0.0142 |
P value <0.05 statistically significant. |