Table 4. ADMET prediction of OXB2.

Parameter	Value /Predictive result	Parameter	Value /Predictive result
Ames mutatest	Negative	HIA	96.623102
SK log S pure	-1.9298	CYP3A4 substrate	Weakly
SK log S buffer	-1.59987	CYP3A4 inhibition	Non
SK log P value	1.15268	CYP2D6 substrate	Non
SK log D value	1.15268	CYP2D6 inhibition	Non
Skin Permeability	-4.1626	CYP2C9 inhibition	Non
Pure water solubility mg/l	2894.73	CYP2C19 inhibition	Non
Plasma Protein Binding	52.137421	Caco2	19.5815
Pgp inhibition	Non	Buffer solubility mg/l	6187.83
MDCK	17.4024	BBB	0.554267
BBB (Blood Brain Barrier): High absorption CNS >2.0, Middle absorption CNS 2.0–0.1, Low absorption CNS <0.1 Caco2: High permeability >70, Middle permeability 4–70, Low permeability >4 HIA (Human Intestinal Absorbance): Well absorbed compounds 70–100%, moderately absorbed compounds 20–70%, Poorly absorbed compounds 0–20%. PPB (Plasma Protein Binding): Strongly Bound >90%, Weakly Bound <90%, MDCK: Higher permeability >500, Medium Permeability 25–500, lower permeability >25.