Skip to main content
. Author manuscript; available in PMC: 2020 Nov 8.
Published in final edited form as: Psychoneuroendocrinology. 2018 Dec 11;102:248–255. doi: 10.1016/j.psyneuen.2018.12.010

Figure 2.

Figure 2.

Disruption of the HPA axis with chronic corticosterone has no effect on stress-induced open field locomotor behavior. (A) Representative heatmap plots for each group showing the patterns of movement in the open field test, with warmer colors representing more time spent in an area. (B) Cumulative time spent in the center of the open field. We observed a main effect of stress (F1, 55 = 90.40, p < 0.001), but no effect of chronic treatment or injection. Stress decreased center time in both Control (p < 0.001) and HPA-X mice (p < 0.001). (C) Number of entries into the center of the open field. We observed a main effect of stress (F1, 55 = 41.53, p < 0.001), but no effect of chronic treatment or injection. Stress decreased center entries in both Control (p < 0.001) and HPA-X mice (p < 0.001). (D) Total distance traveled in the open field. Similar to center time and center entry results, we observed a main effect of stress (F1, 55 = 66.40, p < 0.001), but no effect of chronic treatment or injection. Stress decreased distance traveled in both Control (p < 0.001) and HPA-X mice (p < 0.001). Bars represent means + SEM; ***p < 0.001, n = 7-8 mice/group. Three way ANOVAs were used to analyze data (stress x chronic treatment x injection), and two-tailed Student’s t tests were used to compare differences between stress and chronic treatment groups.