Table II.

Physicochemical Properties of Polymers Commonly Used in the Preparation of Solid Dispersions

SN.	Polymer	Physical form	Molecular weight (g/Mol)	Water solubility	Hygroscopicity	Glass transition/Melting temperature (°C)	Degradation temperature (°C)	Solubility parameter (Mpa1/2)
1	Poly-Vinyl-Pyrrolidone (PVP)
1.1	PVP K-12	Amorphous	5000	Water soluble	High	120a	196	21.74
1.2	PVP K-15	Amorphous	9700	Water soluble	High	130a	215	21.63
1.3	PVP K-30	Amorphous	66,800	Water soluble	High	163a	171	21.69
1.4	PVP K-60	Amorphous	396,000	Water soluble	High	170a	NA	21.70
1.5	PVP K-90	Amorphous	1,570,000	Water soluble	High	174a	194	21.73
1.6	PVP K-120	Amorphous	3,470,000	Water soluble	High	174a	194	21.70
2	Copovidone	Amorphous	45,000–70,000	Amphiphilic	Moderate	100–105	230	21.20
3	Poly ethylene glycol (PEG)
3.1	PEG 400	Crystalline	400	Intermediate	High	NA	NA	18.9
3.2	PEG 600	Crystalline	600	Intermediate	High	NA	160	23.70
3.3	PEG 800	Crystalline	800	Intermediate	High	NA	160	23.70
3.4	PEG 1000	Crystalline	1000	Intermediate	Moderate	37–40	160	23.70
3.5	PEG 1500	Crystalline	1500	Intermediate	Moderate	44–48	160	23.70
3.6	PEG 2000	Crystalline	2000	Intermediate	Moderate	45–50	160	17.6
3.7	PEG 3000	Crystalline	3000	Intermediate	Moderate	48–54	NA	NA
3.8	PEG 4000	Crystalline	4000	Intermediate	Moderate	50–58	NA	NA
3.9	PEG 6000	Crystalline	6000	Intermediate	Moderate	55–63	NA	NA
3.10	PEG 8000	Crystalline	8000	Intermediate	Moderate	60–63	NA	19.8
3.11	PEG 10000	Crystalline	10,000	Intermediate	Moderate	62–65	NA	16.6
3.12	PEG 20000	Crystalline	20,000	Intermediate	Moderate	60–63	NA	NA
4	Hydroxypropyl methylcellulose (HPMC)
4.1	HPMC-E	Amorphous	85,000–150,000	Water soluble	High	141c	NA	29.95b
4.2	HPMC-F	Amorphous	85,000–150,000	Water soluble	High	160c	240	29.05b
4.3	HPMC-K	Amorphous	85,000–150,000	Water soluble	High	172c	260	30.57b
5	Hydroxypropyl methylcellulose acetate succinate (HPMCAS)
5.1	HPMCAS L	Amorphous	50,000	Water soluble above pH 5.0	High	119	204	29.10
5.2	HPMCAS M	Amorphous	50,000	Water soluble above pH 5.0	High	120	190	29.10
5.3	HPMCAS H	Amorphous	50,000	Water soluble above pH 5.0	High	122	NA	29.10
6	Soluplus®	Amorphous	118,000	Amphiphilic	Moderate	70	250	19.40

NA, not available

^aReference (68). ^bHansen solubility parameter reported from (124). ^cDSC data for samples heated from 0 to 230°C at a heating rate of 10°C/min (43), part of the table has been reproduced from reference (88, 172, 173), the molecular weights used in the table are average molecular weights