Table III.

Discernment Table for Choosing Polymer Based on API Properties

Drug property	Poly-vinyl pyrrolidone	Poly-ethylene glycol	Hydroxy propyl methyl cellulose	Soluplus®	Copovidone	HPMCAS
Melting point
High	Yes	No	Yes	Yes	Yes	No
Low	No	Yes	No	Yes	Yes	Yes
Intermolecular interactions
Molecular bonding	Yes	No	Yes	Yes	Yes	Yes
Glass formability
Rich	Yes	Yes	Yes	Yes	Yes	Yes
Poor	Yes	No	Yes	Yes	Yes	Yes
Hygroscopicity
High	No	No	No	Yes	Yes	Yes
Low	Yes	Yes	No	Yes	Yes	Yes
Log P (phase solubility/miscibility)
High	No	No	No	Yes	No	Yes
Low	Yes	Yes	Yes	Yes	Yes	Yes