The prevalence of hyperhidrosis in the USA is estimated to be 4.8%; however, patients may be underdiagnosed, undertreated, and may not seek treatment for symptom relief.

Hyperhidrosis is associated with social and emotional distress, yet rates of diagnosed anxiety and depression have not been evaluated among a large, nationally representative cohort of hyperhidrosis patients.

In this study we evaluated treatment rates and patterns among individuals in the USA diagnosed with hyperhidrosis and estimated the incidence and prevalence of depression and anxiety among these patients.

Many of these patients with hyperhidrosis did not receive treatment for their condition, and compared to matched controls, patients with hyperhidrosis had higher adjusted odds of depression and/or anxiety (odds ratio 1.76, 95% confidence interval 1.72–1.80, p < 0.001).

Hyperhidrosis may have a considerable impact on the quality of life and mental health which may be comparable to that associated with other chronic and impactful conditions.

Providers who treat hyperhidrosis should recognize the potential for comorbid anxiety and depression, and screening for these conditions and linking patients with mental health resources may help to improve patients’ overall health and well-being.