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. 2020 Nov 4;12:11271–11283. doi: 10.2147/CMAR.S255895

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© 2020 Zhu et al.

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CDK1 up-regulation in fluorouracil-resistant CRC cell.

Notes: (A) Relative expression of CDK1 protein in colorectal mucosal epithelial cells (NCM460) and four CRC cell lines (SW620, SW480, HT-29, HCT116) was detected by Western blot. (B and C) IC50 of HT-29 and HT-29/5-Fu was detected by MTT. (D and E) IC50 of SW480 and SW480/5-Fu was detected by MTT. (F) The relative expression of CDK1 mRNA in fluorouracil-sensitive cells and fluorouracil-resistant cells. Quantity of protein was analyzed by Image J software. *P<0.05, ***P<0.001.