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. 2020 Oct 20;23(11):101709. doi: 10.1016/j.isci.2020.101709

Figure 2.

Figure 2

Deletion of FcRγ Yields Reduced NK Cell Responsiveness to K562 and Raji Tumor Cells

(A) Contour plots show flow cytometric analysis of CD107a expression by FcRγ+ and FcRγ− NK subsets from a representative donor following incubation in the absence (−) or presence (+) of K562 tumor cells. Numbers represent the relative percentages of FcRγ+ or FcRγ− subset that displayed CD107a. Line graph shows the relative percentages of FcRγ+ or FcRγ− subsets that displayed CD107a from several donors in response to K562 stimulation (n = 8). Circles connected by a line designate data obtained from the same donor sample.

(B and C) Contour and dot plots show the percentages of FcRγ+ and FcRγ− subsets that produced (B) TNF-α or (C) IFN-γ in response to K562 stimulation.

(D–F) Line graphs show the relative percentages of FcRγ+ and FcRγ− subsets that displayed (D) CD107a or (E) produced TNF-α or (F) IFN-γ in response to Raji stimulation. (G) Contour plots and line graphs show the percentages of FcRγ+ and FcRγ− subsets that produced IFN-γ in response to stimulation with IL-12 plus IL-18. Wilcoxon signed-rank test; ∗p < 0.05, ∗∗p < 0.01, n.s., not significant.