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. 2020 Oct 20;23(11):101709. doi: 10.1016/j.isci.2020.101709

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© 2020 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Deletion of PLZF in NK Cells Does Not Affect Responsiveness to CD16

(A) Contour plots show the expression of PLZF in NK cells following nucleofection with ZBTB16-targeting Cas9/gRNA ribonucleoprotein (ZBTB16-RNP). Data are representative of 4 independent experiments performed on NK cells from 7 donors.

(B–D) Line graphs show the relative percentages of PLZF⁺ and PLZF⁻ subsets that produced (B) TNF-α, (C) IFN-γ or (D) displayed CD107a from several donors in response to CD16 CXL (n = 7). Circles connected by a line designate data obtained from the same donor. n.s., not significant.