Figure 1.

Desmin knock-out mice show reduced muscle strength and have a lower body weight with advancing age. (A) For 3–4 months old desmin knock-out mice, a total of three wild-types and four mutant mice were measured. For 7–8 months old desmin knock-out mice, a total of four wild-types and five mutant mice were measured. Statistical significance was determined by unpaired two-tailed t-test (**P < 0.01). (B) Newton meter measurements of muscle force of desmin mutant mice showed significant muscle weakness. For 3–4 months old desmin knock-out mice, a total of three wild-types and four mutant mice were measured. For 7–8 months old desmin knock-out mice, a total of four wild-types and five mutant mice were measured. Statistical significance was determined by unpaired two-tailed t-test (***P < 0.001).