Skip to main content
. 2020 Oct 26;10:585727. doi: 10.3389/fcimb.2020.585727

Table 1.

Comparison of the temporal course of retinal development in mice and in humans.

Developmental milestone Mouse Human
Formation of the optic cup E9–9.5 (Heavner and Pevny, 2012) GW5 (Smirnov and Puchkov, 2004)
Pigmented epithelium layer separated from the visual layer From E13 (Fan et al., 2016) From GW6 (Smirnov and Puchkov, 2004)
Ganglion cells generation period E11–E19 (HRP retrograde labeled cells and 3H-Thy; Dräger, 1985)
E8–E16 (peak E12) (Brn3a labeled cells and BrdU; Voinescu et al., 2009)
GW6 to GW14 in the fovea (finishing at GW30 in the whole retina)
IPL appearance E17 (Fan et al., 2016) GW8-9 in the fovea; GW15 temporal and GW18 far periphery (Hendrickson, 2016)
OPL formation P4–P5 (Olney, 1968) GW11 (fovea); GW30 (far periphery) (Hendrickson, 2016; Hendrickson and Zhang, 2017)
Ganglion cell PCD Peak P2–P4 (Young, 1984) and P15 (Péquignot et al., 2003) Peak GW15–20 (Georges et al., 1999)
PCD in the INL Inner INL P0–P11 (peak P4–P6)
Outer INL P5–P18 (peak P8–P10) (Young, 1984)
From GW15–35 (peak GW20) mainly in the bipolar location
PCD in the ONL Inner rods P5–P11 (peak P7–8)
Outer rods P5–P21/24 (peak P15, Young, 1984; Péquignot et al., 2003)
Significantly lower than other layers (GW15-GW35)
Synapses in the IPL Conventional synapses P5 (Fisher, 1979)
Ribbon synapses P10–P12 (Olney, 1968; Fisher, 1979)
GW12 (future fovea) (Hollenberg and Spira, 1973)
Synapses in the OPL P7 (Olney, 1968) GW12 in the future fovea (Hollenberg and Spira, 1973)
Invasion of vascular cells from optic disc From P2 (Young, 84) From GW14-15 (Hughes et al., 2000)

E, Embryonic day; P, Post-natal day; PCD, Programmed Cell Death; GW, Gestational week.