Table 4.
Univariate and multivariate Cox analysis for these patients in the training cohort.
| Variables | Univariate Cox analysis | P value | Multivariate Cox analysis | P value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age (years) | ||||
| <65 | Reference | Reference | ||
| >= 65 | 1.18 (1.02-1.36) | 0.024 | 1.25 (1.08-1.45) | 0.003 |
| Sex | ||||
| Female | Reference | Reference | ||
| Male | 1.45 (1.27-1.65) | <0.001 | 1.28 (1.08-1.51) | 0.004 |
| Race | ||||
| White | Reference | — | ||
| Black | 0.98 (0.80-1.20) | 0.865 | — | |
| Other | 1.07 (0.85-1.35) | 0.558 | — | |
| Histology of lung cancer | ||||
| Adenocarcinoma | Reference | Reference | ||
| Squamous cell carcinomas | 1.21 (1.02-1.42) | 0.024 | 1.21 (1.03-1.43) | 0.022 |
| Small cell cancer | 2.13 (1.73-2.62) | <0.001 | 1.34 (1.08-1.65) | 0.007 |
| Others | 0.87 (0.74-1.02) | 0.089 | 1.13 (0.96-1.32) | 0.147 |
| Location of FPC | ||||
| Prostate | Reference | Reference | ||
| Female Breast | 0.67 (0.53-0.84) | <0.001 | 1.21 (0.91-1.61) | 0.199 |
| Urinary Bladder | 1.29 (1.03-1.61) | 0.024 | 1.53 (1.23-1.92) | <0.001 |
| Others | 0.85 (0.72-0.99) | 0.046 | 1.35 (1.13-1.61) | <0.001 |
| Stage of lung cancer | ||||
| Stage I | Reference | Reference | ||
| Stage II | 1.74 (1.35-2.23) | <0.001 | 1.80 (1.44-2.32) | <0.001 |
| Stage III | 2.70 (2.23-3.29) | <0.001 | 1.80 (1.46-2.21) | <0.001 |
| Stage IV | 6.36 (5.39-7.51) | <0.001 | 3.90 (3.24-4.70) | <0.001 |
| Surgery | ||||
| No | Reference | Reference | ||
| Yes | 0.22 (0.18-0.25) | <0.001 | 0.36 (0.30-0.44) | <0.001 |
| Interval (months) | ||||
| <24 | Reference | — | ||
| 24 - 47 | 1.08 (0.94-1.24) | 0.277 | — | |
| 48 - 72 | 0.86 (0.65-1.13) | 0.276 | — | |
| Year of diagnosis (year) | ||||
| 2010 | Reference | — | ||
| 2011 | 1.03 (0.74-1.45) | 0.852 | — | |
| 2012 | 1.06 (0.76-1.47) | 0.741 | — | |
| 2013 | 1.14 (0.83-1.58) | 0.424 | — | |
| 2014 | 1.06 (0.77-1.47) | 0.702 | — | |
| 2015 | 0.88 (0.63-1.22) | 0.441 | — |