Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 26;11:556813. doi: 10.3389/fimmu.2020.556813

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Alvarez, Jones, Hambor and Cobb

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Gene set enrichment analysis of inflammatory and interferon related genes. Gene ontology and gene set enrichment analysis were conducted on differentially expressed genes (FDR > 0.05 and log2CPM > 0). (A) Gene ontology analysis of differentially expressed genes increased (red) and decreased (blue) with PSA exposure in CD4⁺ T cells. GO terms with immunological relevance were extracted (44 terms). Gene ontology terms significantly associated (P ≤ 0.05) were plotted as −log10 version. (B) Hallmark gene set enrichment analysis of PSA stimulated cells. Gene sets significantly associated (P ≤ 0.05) were plotted as −log10 of q value. GSEA analysis showing enrichment in (C) IFN-γ, IFN-α and inflammatory response gene sets, (D) TNF superfamily members and receptors, (E) and gene sets associated with Treg functionality.