FBP17L Contains a Conserved IDR
(A) Aligned alternatively spliced isoforms of human FBP17. The ∗ is shown below at each position when the residue is conserved. Negative and positive amino acids are shown in orange and green, respectively. The IDR is highlighted in yellow. PolyP region is underlined.
(B) Intrinsic disorder prediction of human FBP17L by IUPred2A (red), and protein-binding prediction by ANCHOR2 (blue).
(C) Top: WebLogo of the IDR of FBP17 from all 299 species that have FBP17. Blue: hydrophilic amino acid. Green: neutral amino acid. Black: hydrophobic amino acid. Bottom: Sequence alignment of the IDR from human FBP17L and the consensus sequence from WebLogo 3.
(D) Top: WebLogo of the IDR of CIP4 from all 183 species that have CIP4. Bottom: Sequence alignment of the IDR from human CIP4 and the consensus sequence from WebLogo 3.