Figure 2.

Separate roles of GFI1 and GFI1B during definitive hematopoiesis. Schematic representation of hematopoiesis from the initial production of primordial definitive hematopoietic stem cells (HSCs) from the hemogenic epithelial cells (HEs) found in the aorta-gonad-mesonephros (AGM) through endothelial-to-hematopoietic transition (EHT) during embryonic development until the production of all blood cells in the definitive hematopoietic sites such as fetal liver and adult bone marrow. Cellular compartments in which GFI1 plays a role are indicated as a blue area, whereas the compartment where GFI1B is important are indicated as the yellow areas, highlighting both overlapping and exclusive functions of GFI1 and GFI1B at all stages of hematopoiesis. Factors that contribute to cell fate decisions along with GFI1 or GFI1B are indicated. LMPP, lymphoid-primed multipotent progenitors; CMP, common myeloid progenitors; CLP, common lymphoid progenitors; GMP, granulocyte-monocyte progenitors; MEP, megakaryocyte-erythrocyte progenitors; MkP, megakaryocyte progenitors; Eosino, eosinophils; Neutro, neutrophils; Baso, basophils; DCs, dendritic cells; NK, natural killer cells.