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. 2020 Oct 26;11:593273. doi: 10.3389/fgene.2020.593273

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Copyright © 2020 Zhang, Zhang, Gao, Fan, Dai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic effects of KPNA2 and its correlated BCR signaling pathway genes in HCC. (A) Prognostic effects of KPNA2 and its correlated BCR signaling pathway genes on overall survival of the TCGA-HCC patients through univariable Cox regression analysis. (B) Prognostic effects of KPNA2 and its correlated BCR signaling pathway genes on overall survival of the ICGC-HCC patients through univariable Cox regression analysis. (C–F) The gender-age-stage-corrected prognostic effects of KPNA2, GRB2, NRAS, and BLNK on OS of the TCGA-HCC patients, respectively. (G–J) The gender-age-stage–corrected prognostic effects of KPNA2, GRB2, NRAS, and BLNK on overall survival of the ICGC-HCC patients, respectively. For (A,B), univariable Cox regression analysis was used. For (C–J), multivariable Cox regression analysis was performed. The analyses were performed with R software, and p < 0.05 was considered statistically significant.