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. 2020 Oct 26;11:593273. doi: 10.3389/fgene.2020.593273

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Copyright © 2020 Zhang, Zhang, Gao, Fan, Dai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic roles of KPNA2, GRB2, and NRAS in HCC at protein level. (A) Higher expression of KPNA2 indicated shorter survival in HCC patients. (B) Higher expression of GRB2 indicated shorter survival in HCC patients. (C) Higher expression of NRAS indicated longer survival in HCC patients. (D–F) Prognostic effects of KPNA2, GRB2, and NRAS on HCC overall survival when adjusted for gender, age, and tumor size. Paired-samples Wilcoxon test was used for protein level comparisons. Kaplan-Meier survival analysis with log-rank test and multivariable Cox regression analysis were used for evaluation of the prognostic effects of the proteins. For all the analyses, p < 0.05 was considered statistically significant.