Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 26;10:589508. doi: 10.3389/fonc.2020.589508

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Wang, Liu, Fan, Zhou, Li, Macvicar, Dong, Bruns and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Glutamine metabolism in cancer. Cancer cells uptake glucose and glutamine through GLUT and ASCT2, respectively. After transporting into cells, glutamine is catalyzed to glutamate by glutaminases, which have two isoforms: GLS1 and GLS2. Glutamate is further converted to α-KG through GLUD or aminotransferases. The resulting metabolites can supply for bioenergetics through tricarboxylic/critic acid (TCA) cycle and support biosynthesis of proteins, nucleotides and lipids. In addition, glutamine metabolism also contributes directly to GSH synthesis. The regulation of glutaminase is marked in pink.