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. 2020 Oct 26;14:538404. doi: 10.3389/fnins.2020.538404

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Copyright © 2020 Rathore, Arora, Rastogi, Akhtar, Singh and Samim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Photographs showing effect of nanosilymarin on brain infarct in control (C), ischemic (I), NS1 (10 μg/kg b.wt), NS2 (100 μg/kg b.wt), NS3 (1,000 μg/kg b.wt), and free silymarin (Sil) (100 mg/kg b.wt), respectively. Infarct region is very well visible in the ischemic group (I) brain sections as compared to the control (C) group brain sections, and all the three treatment groups showed a significant reduction in infarct region in comparison to free silymarin group. (B) Quantification of infarct analysis. The experiment was conducted for n = 3 data sets, and results are shown as mean ± SEM. Results on comparison with the control group showed a significant difference (^###p < 0.001). Results showed a significant difference from the ischemic group (^nsp > 0.05 and ^∗∗∗p < 0.001).