Table 3:

Multivariable analysis to identify risk factors associated with overall survival (a). Individual treatment comparisons were evaluated within the multivariate model to identify how treatment independently impacted survival (b).

a)
Parameter	HR (95% CI)	P value
Age (years)
<45	Reference
45–60	1.17 (0.85, 1.62)	0.337
>60	2.25 (1.60, 3.16)	<0.001*
Comorbidity Score ≥ 2	1.64 (1.01, 2.66)	0.044*
Community / Network Facility vs Academic	1.46 (1.14, 1.85)	0.002*
Income below median	1.19 (0.95, 1.48)	0.125
Insurance
Private	Reference
Government	1.71 (1.27, 2.31)	<0.001*
Not Insured	1.87 (1.02, 3.45)	0.044*
Race
White	Reference
Asian	0.82 (0.48, 1.39)	0.457
Black	0.76 (0.46, 1.26)	0.282
Other	0.60 (0.32, 1.15)	0.124
Male Sex	1.13 (0.91, 1.41)	0.253
Tumor Size ≥ 5 cm	1.52 (1.16, 1.99)	0.002*
Metastatic	3.08 (1.86, 5.11)	<0.001*
Margins
Negative	Reference
Positive	1.54 (1.11, 2.13)	0.011*
No Surgery	2.06 (1.52, 2.78)	<0.001*
RT Modality: Dose (Gy)
None	Reference
Advanced: <40	1.33 (0.56, 3.15)	0.512
Advanced: 40–65	1.10 (0.72, 1.68)	0.666
Advanced: >65	0.78 (0.52, 1.18)	0.241
Advanced: SRS	0.91 (0.58, 1.42)	0.666
Conventional: <40	1.80 (1.10, 2.93)	0.019*
Conventional: 40–65	1.25 (0.88, 1.77)	0.221
Conventional: >65	1.02 (0.58, 1.80)	0.945

b)
Comparison	HR (95% CI)	P value
RT: Advanced >40 Gy vs Conventional	0.71(0.49, 1.02)	0.061
RT: Advanced >65 Gy vs Conventional	0.60 (0.38, 0.93)	0.024*
RT: Advanced >65 Gy vs Conventional ≤65 Gy	0.52 (0.33, 0.84)	0.007*
RT Advanced: >65 Gy vs ≤65 Gy	0.65 (0.35, 1.19)	0.161
RT Dose: >65 Gy vs ≤65 Gy	0.67 (0.43, 1.03)	0.071
RT Modality: Advanced vs Conventional	0.77 (0.53, 1.11)	0.164
RT: No vs. Yes	0.88 (0.69, 1.12)	0.315
Surgery: No vs. Yes	1.66 (1.28, 2.15)	<0.001

^*Statistical Significance

Note: RT=Radiation Therapy.

^*Statistical Significance