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. Author manuscript; available in PMC: 2020 Nov 9.
Published in final edited form as: Trends Biochem Sci. 2020 Apr 6;45(7):578–592. doi: 10.1016/j.tibs.2020.03.008

Figure 1. The Hallmarks of Organismal Aging.

Figure 1.

Organismal aging (center) is a complex process contributing to progressive decline of organ functionality and regenerative potential of tissues. The aging clock is governed by interconnected hallmarks of organismal aging. Understanding how the underlying biological mechanisms of aging correlate with and impact longitudinal changes in health trajectories might offer an opportunity to identify resilience mechanisms, their dynamic changes, and their impact on physiological integrity. In geroscience, a research field that is rapidly progressing in the current era of precision medicine, novel antiaging agents developed to delay organismal aging will significantly rely on their safety and effectiveness at the level of cells, basic biological units of an individual (outside the circle).