Fig. 1.

Global connectivity results. Patients with late-life MDD showed lower global connectivity degree in the right caudal LC in comparison to aMCI and HC groups. (A) Basal and sagittal view of the LC cluster (in light blue) and peak coordinate (dark blue) (p_FWE < 0.05, TFCE corrected). The cluster is overlaid onto the LC study-specific mask (red contour, see Supplementary material for details). This mask was down-sampled to the resolution of the functional time-series. As can be observed, our cluster was located in the most caudal part of the LC. (B) Box-plot depicting global connectivity degree of the right caudal LC cluster for the three study groups. Values in the Y axis are normalized to fit a Gaussian distribution with zero mean and unitary variance, and, therefore, negative values should not be interpreted as negative connectivity. L = Left, R = Right. *p_FWE < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)