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Frequent voidings were elicited in mice during continuous infusion cystometry (30 μl/min) with diluted acetic acid (pH 3.0). These recordings are from 2 different mice. (A) I.p. injection of vehicle produced little effect on the hyperactive bladder. (B) A-317567 (i.p.) alleviated the acetic acid-induced bladder hyperreflexia. The effect lasted for approximately 10 min.
