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. 2020 Oct 22;7:544412. doi: 10.3389/fmed.2020.544412

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Copyright © 2020 Bindoli, Galozzi, Magnani, Rubin, Campi, Doria, Cecchin and Sfriso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Example of an ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography with magnetic resonance (PET/CT-MR) scan at disease onset. (a) MR whole-body image, T1 turbo spin echo, coronal (WB_t1_tse_cor), (b) fused image, and c) PET acquisition image with attenuation correction (PET_AC). This scan shows a diffusely increased FDG uptake in the bone marrow (SUVmax 4.12), in the spleen (SUV max 3.13), and in the submandibular lymph nodes (SUVmax 5.61). The patient was diagnosed with adult-onset Still's disease (AOSD) and started therapy with glucocorticoids after acquiring the images. (B) ¹⁸F-FDG PET/CT-MR was repeated in four patients. The arrows state the moment IL-1 inhibitory therapy was started during the follow-up showing the decrease in bone marrow uptake.