TABLE 1.

Neuronal diversity and function of PNS sensory ganglia in adult mouse.

Ganglia	Neuronal types	Fiber types	Detected and/or transmitted information	Identified subtypes	Markers expressed by mature neurons	Ref. to scRNA seq studies
TG	Mechanoreceptors C-LTMR Thermoceptors Pruriceptors Nociceptors	Aβ C Aδ or C	Touch Light touch Heat and cold Irritants Noxious heat, cold, touch, chemicals	3 1 10	Piezo2, TrkB, Nav1.5 TH, Vglut3 TrpM8, Gpr26 Cd34, Piezo2, P2Y1 MrgpA3, Etv1, TrpA1, TrpV1, Tac1, CGRP, Scn10a, Grik1, MrgprD	Nguyen et al. (2017, 2019); Sharma et al. (2020)
GG	Mechanoreceptors	A	General touch	>1?	Drg11, Fxyd2, Kcns3, Brn3a, Brn3b, Piezo2	Dvoryanchikov et al. (2017); Anderson and Larson (2019); Zhang et al. (2019)
	Chemoreceptors (gustatory)	C	Sour Sweet Bitter? Umami? Salt? Mechano-sensitive?	[3–6]	Phox2b, P2X3, P2X2 Penk, Lypd1, Htr3a Spon1, Tac1, Itm2a Cdh13 Cdh4 Egr2 Piezo2
VAG	AG type I AG type II VG mechanoreceptors	A A A	Sound vibration Acceleration, gravity	Type I: >3? Type II: 1 VG: N.D.	Runx1, Calb1, Ttn Lypd, Brn3a, Grm8 Trim54, Calb2, Rxrg TH, Periph, Mafb	Petitpré et al. (2018); Shrestha et al. (2018); Sun et al. (2018)
PNG	Nociceptors Chemoreceptors Mechanosensors	C C A or C	Inflammation Irritants, nutrients, Stretch, pressure	PG: N.D. NG: 18	Phox2b, P2X2, Nav1.8, Trpv1, Hoxb2-6, Tbx3, TrkC, Eya1, Nav1.1, Piezo2, P2Y1, Gpr65, Npy2r, Glp1r	Williams et al. (2016); Kupari et al. (2019); Mazzone et al. (2020)
SJG	Thermoceptors Pruriceptors Nociceptors	Aδ or C	Light touch Irritants Noxious heat, cold, touch, chemicals	SG: N.D. JG: 6	TH, Runx1, Drg11 TrpV1, TrkA, CGRP, Prdm12, TrpM8, Asic3	Kupari et al. (2019)
DRG	Proprioceptor Mechanoreceptor C-LTMR Thermoceptors Pruriceptors Nociceptors	Aα Aβ C Aδ or C	Limb position Touch Light touch Heat and cold Irritants Noxious heat, touch, chemical	[1–2] [2–3] 1 >5	TrkC, Parv, Runx3 TrkB, Ret, MafA Piezo2, TH, Vglut3 TrpV1, TrpM8, TrpA1, Piezo2, TH, P2X3, SST, Nav1.8, Nav1.7, TrkA, Runx1, TrpV1, TrpA1, MrgprD	Chiu et al. (2014); Usoskin et al. (2015); Li et al. (2016); Zeisel et al. (2018); Hockley et al. (2019); Sharma et al. (2020)

TG, trigeminal ganglia; GG, geniculate ganglia; VAG, vestibuloacoustic ganglia; PNG, petrose and nodose ganglia; SJG, superior and jugular ganglia; DRG, dorsal root ganglia.