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. 2020 May 18;11(8):885–895. doi: 10.1039/d0md00057d

Table 3. Exploration of fused rings as potential linker.

Inline graphic
Compound number Ar T. brucei a EC50 (nM) CRL-8155 b CC50 (nM) HepG2 c CC50 (nM)
30 graphic file with name d0md00057d-u32.jpg 31 >50 000 >50 000
31 graphic file with name d0md00057d-u33.jpg 24 ± 6 (n = 2) 13 000 >50 000
32 graphic file with name d0md00057d-u34.jpg >2000 ND d ND
33 graphic file with name d0md00057d-u35.jpg 32 >50 000 >50 000

aControl for T brucei EC50 assay average ± SEM: pentamidine (1.8 ± 0.3 nM, n = 7).

bControl for CRL-8155 CC50 assay average ± SEM: quinacrine (4.8 ± 1.0 μM, n = 4).

cControl for HepG2 CC50 assay average ± SEM: quinacrine (10.0 ± 2.0 μM, n = 3).

dND: not determined.