Table 3. Exploration of fused rings as potential linker.

Compound number	Ar	T. brucei a EC50 (nM)	CRL-8155 b CC50 (nM)	HepG2 c CC50 (nM)
30		31	>50 000	>50 000
31		24 ± 6 (n = 2)	13 000	>50 000
32		>2000	ND d	ND
33		32	>50 000	>50 000

^aControl for T brucei EC₅₀ assay average ± SEM: pentamidine (1.8 ± 0.3 nM, n = 7).

^bControl for CRL-8155 CC₅₀ assay average ± SEM: quinacrine (4.8 ± 1.0 μM, n = 4).

^cControl for HepG2 CC₅₀ assay average ± SEM: quinacrine (10.0 ± 2.0 μM, n = 3).

^dND: not determined.