Table 4. Additional inhibitors with 2,5-substituted imidazo[1,2-a]pyridine linker.

Compound number	Ar	R	T. brucei a EC50 (nM)	CRL-8155 b CC50 (nM)	HepG2 c CC50 (nM)
34		Cl	1900	ND d	ND
35		Cl	64	16 100	43 200
36		Cl	196	ND	ND
37		Cl	1780	ND	ND
38		Cl	>2000	ND	ND
39		Cl	3.5 ± 0.1 (n = 2)	9500	>50 000
40		Cl	3.1 ± 0.5 (n = 6)	19 000	28 200
41		F	59	15 700	>50 000
42		F	8.4 ± 3.1 (n = 2)	10 400	>50 000
43		F	7.2 ± 1.7 (n = 4)	>25 000	>25 000

^aControl for T brucei EC₅₀ assay average ± SEM: pentamidine (2.4 ± 0.3 nM; n = 10).

^bControl for CRL-8155 EC₅₀ assay average ± SEM: quinacrine (6.1 ± 0.6 μM; n = 5).

^cControl for HepG2 EC₅₀ assay average ± SEM: quinacrine (10.9 ± 1.1 μM; n = 4).

^dND: not determined.