Figure 2.

Quantitation of PBR-TSPO in NSCLC and melanoma. (A-B) PBR, also known as TSPO, protein is present at high levels in human monocytes, but expression is decreased in human NSCLC (P = 0.0038 by t test, mean 0.38 ± 0.045 standard error of the mean [SEM]) and human melanoma (P = 0.0008, 0.40 ± 0.089) cell lines. (C) Human NSCLC (n = 28) and (D) melanoma (n = 13) tissue microarrays were stained with either cytokeratin or S100, respectively, to create a tumor mask. PBR-TSPO immunofluorescence staining intensity was quantitated in tumor cells by AQUA. Representative sections demonstrating tissue with higher and lower PBR-TSPO expression is shown for NSCLC and melanoma cases.