Table 1.
Patient ID | Diagnosis | Tumor location | Sex | Age | Mutations | Months since SRS | Radiation dose (Gy) | Systemic therapy | Concurrent steroids | [11C]MET | [11C]PBR28 | Pathology | Imaging follow-up (Months) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Melanoma | Right frontal | M | 82 | BRAF mutant | 13.4 | 20 | ArQule-736 (pan-RAF inhibitor); nivolumab | None | + | + | Tumor with RN | |
2 | NSCLC | Right frontal | F | 55 | None | 21.3 | 22 | Cisplatin/etoposide | None | + | + | Tumor | |
3 | Melanoma | Right frontal | M | 56 | BRAF wild-type | 20.1 | 20 | High dose IL-2; ipilimumab; pembrolizumab | None | – | – | RN | |
4 | NSCLC | Left frontal | F | 63 | None | 11.9 | 18 | Carboplatin/pemetrexed | Yes | – | – | Presumed RN | 8.5 |
Right parietal | 11.9 | 18 | – | – | Presumed RN | 8.5 | |||||||
5 | NSCLC | Right frontal | M | 62 | KRAS mutant | 8.3 | 18* | Carboplatin/paclitaxel | Yes | – | + | Presumed RN | 12.5 |
Left frontal | 8.3 | 18* | – | + | RN |
* Patient also had prior WBRT.