Table 3.
Variable | Category | Univariate analysis |
Multivariate analysis |
||
---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | ||
Age, years | ⩾61 versus <61 | 0.78 (0.59−1.03) | 0.09 | 0.81 (0.60−1.08) | 0.16 |
Sex | Female versus male | 1.33 (0.97−1.83) | 0.07 | 1.35 (0.87−2.07) | 0.17 |
Smoking history | Yes versus no | 0.92 (0.69−1.22) | 0.57 | 1.24 (0.83−1.85) | 0.28 |
Histology | Squamous versus non-squamous | 0.87 (0.64−1.17) | 0.36 | 0.80 (0.58−1.10) | 0.18 |
Stage | IV versus III | 0.98 (0.66−1.47) | 0.96 | 0.81 (0.52−1.24) | 0.34 |
ECOG PS | ⩾2 versus 0−1 | 1.12 (0.61−2.03) | 0.71 | 1.07 (0.56−2.05) | 0.82 |
Treatment type | Combination therapy versus monotherapy | 0.75 (0.57−0.99) | <0.05 | 0.73 (0.54−0.99) | <0.05 |
Prior lines of therapy | 1 line versus 2 lines versus ⩾3 lines | 1.24 (1.04−1.42) | 0.01 | 1.16 (0.9−1.42) | 0.13 |
Brain metastasis | Yes versus no | 1.70 (1.18−2.44) | <0.01 | 1.40 (0.95−2.05) | 0.08 |
Baseline Hb, g/L | ⩾110 versus <110 | 0.63 (0.47−0.83) | <0.01 | 0.67 (0.50−0.91) | 0.01 |
CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group Performance Status; Hb, hemoglobin; HR, hazard ratio.