Scheme 7. Synthesis of cyanopurine 102. Reagents and conditions: (a) aniline, TFA, TFE, 80 °C, 18 h; (b) PhNMe2, POCl3, 115 °C, 1 h; (c) 4-methoxybenzyl chloride, K2CO3, DMF, 60 °C, 18 h; (d) Et4NCN, DABCO, MeCN, rt, 18 h; (e) TFA, 70 °C, 5 h.
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