Table 5. In vitro ADME properties for 66 (Cyprotex Discovery, Macclesfield, UK).

Microsomal stability
Microsomal stability (human)				Microsomal stability (mouse)
CLint (μL min–1 mg–1)	S.E. CLint	T 1/2 (min)	n	CLint (μL min–1 mg–1)	S.E. CLint	T 1/2 (min)	n
6.21	0.681	223	5	10.2	1.82	136	5

Solubility
Estimated precipitation range (μM)
Lower bound			Upper bound			Calculated mid-range
100			>100			>100

Caco-2 permeability
Direction	Papp (× 10–6 cm–1)		Mean Papp (× 10–6 cm–1)	SD	n	Mean recovery (%)
	1	2
A → B	0.0534	0.0421	0.0477	0.00799	2	57.6
B → A	4.88	5.29	5.08	0.293	2	64.0