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. 2020 Sep 25;2(1):vdaa127. doi: 10.1093/noajnl/vdaa127

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — The faster switch in macrophage polarization in the secondary tumors is mediated by the transplanted TME. (A) Schematic depicting the experimental approach. (B) Immunofluorescent staining of sections of 4 + 2 weeks tumor from complete TME and tumors from tumor cells only. Scale bar: 100 µm; 50 µm z-stack. Quantification of M1- and M2-positive macrophages. N = 10 (both groups); 5 fields of view/tumor. *P < .05. (C) Immunofluorescent staining and quantification of F4/80⁺ macrophages in 4 + 2 weeks tumor from complete TME and tumors from tumor cells only. Scale bar: 100 µm; 50 µm z-stack. N = 10 (complete TME) and 9 (tumor cells) tumors; 5 fields of view/tumor. (D) Tumor size of 4 + 2 weeks tumors from complete TME and tumors from tumor cells only. N = 10 (complete TME) and 8 (tumor cells) tumors. Data shown: mean + SEM (B–D).