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. 2020 Sep 25;2(1):vdaa127. doi: 10.1093/noajnl/vdaa127

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Secondary tumors display more aggressive growth than primary. (A) Days of primary and secondary tumor growth until symptoms of tumor burden are observed. N = 30 (4 weeks) and 25 (4 + 4 weeks) animals. ****P < .0001. (B) Percentage of body weight loss in mice bearing primary or secondary tumors as measured at humane end-point. **P < .01. (C) Tumor volume of primary and secondary tumors. **P < .01. (D) F4/80⁺ macrophages in primary and secondary tumors. *P < .05. (E) Number of M2 (CD206+) macrophages in primary and secondary tumors. Each dot represents 1 mouse/tumor (A–E). Data shown as mean ± SEM (A–E).