Schematic depiction of the mechanisms of action of decorin-evoked endothelial cell autophagy (left) or decorin-mediated tumor cell mitophagy (right) on distinct compartments within the tumor such as the tumor microenvironment and tumor parenchyma (center). Please consult the manuscript for additional details. Abbreviations: AMPK, activated protein kinase; GFP, green fluorescent protein; mtDNA, mitochondrial DNA; mTOR, mammalian target of rapamycin; OXPHOS, oxidative phosphorylation; Peg3, paternally expressed gene 3; TFEB, transcription factor EB; VDAC1, voltage-dependent anion channel 1; VEGFR2, vascular endothelial growth factor receptor 2.