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Pericellular matrix compaction is increased by HAPLN1. Hyaluronan staining in (A) control; (B) HABP-treated; and (C) versican-treated cells. The outlines indicate examples of regions of interest selected for quantitation of staining density of the pericellular matrix. (D) percent of the area stained for hyaluronan in each treatment as a measure of matrix compaction. Bar equals 25 µm. Abbreviations: HABP, hyaluronan binding protein; HAPLN1, hyaluronan and proteoglycan link protein 1.
