Table 3.

Assessment of Progression of APAP-Induced Liver Injury

Process	Marker	Samples Needed	Reference(s)
Release of DAMPs	HMGB1	Liver and serum	66,67
	Mitochondrial DNA	Serum	65
Inflammation	Ly6G and F4/80	Liver sections (IHC or IF)	13,82
	Cytokines measurements	Liver (for mRNA) and serum (for secreted protein)	13,82