Table 4.

Assessment of Liver Regeneration After APAP Overdose

Process	Marker	Sample Needed	Reference(s)
Cell proliferation	PCNA/Ki-67/mitotic index	Liver sections	10,45
Cell cycle	Cyclins D, E, A, and B; pRb and CDK4	Liver (mRNA or protein)	10,41
Stimulus	Cytokines and their receptors (IL6/STAT3; TNF-α/NF-κB)	Liver (for mRNA/protein) and serum (for secreted protein)	10,78
	Growth factors and their receptors (HGF/MET; EGFR ligands/EGFR)	Liver (for mRNA or protein) and serum (for secreted protein)	10,45