Figure 5. Anti-CXCR3 treatment leads to enhanced autoantibody production.
Anti-CXCR3 antibody or IgG was i.p.-administered to 4-week-old female NOD mice 3 times weekly for 6 weeks. (A) Detection of serum ANA. Original magnification: ×400. Bar graph shows the fluorescence intensity of ANA staining. (B) Analyses of serum anti-M3R autoantibody level by ELISA. Data are representative or the average of analyses of 12–15 mice for each group.