Fig. 2.

a Disease onset and temporal evolution characteristics of distinguishable clinical patterns and different causes of peripheral neuropathy. b Clinical patterns of polyneuropathy: Sensory deficits are drawn in blue, motor deficits are drawn in red, and sensorimotor in magenta color. Painful and / or autonomous dysfunction is colored with green lines. Loss of proprioception is colored in brown. Pattern #1 is a distal symmetric predominantly sensory neuropathy, #2 a motor neuropathy with muscle wasting and foot abnormalities; pattern #3 is characterized by proximal involvement of sensory and motor nerve fibers, pattern #4 presents wih multifocal symptoms, neuropathic pain, and autonomic dysfunction. Pattern #5: is a sensory ataxic neuropathy