Table 1.

Diagnosis of exclusion of other causes of pneumonitis in our patient, based on the Spanish Pharmacovigilance System Algorithm (SPSA) [15]

SPSA factor	Our patient	Points assigned
Chronology Did the adverse event occur after drug exposure?	Yes	2
Criteria from the literature Have other cases been reported?	Yes Two cases [13, 14]	1
Outcome of the adverse reaction after drug discontinuation Did the patient improve when the drug was stopped?	Yes Dyspnea disappeared within 4 days	2
Rechallenge Was treatment resumed after improvement?	No	0
Other possible causes Were other causes ruled out?	Yes Negative cultures showed no infection	1
Contributory factors Are there other factors favoring a causal relationship?	No	0
Investigations Is there any evidence of drug concentration in a biological fluid or biopsy?	No No analyses were performed	0
Total number of points	6