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. 2020 Nov 9;39:235. doi: 10.1186/s13046-020-01739-z

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© The Author(s) 2020, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — MYLK-AS1 regulates HCC cell proliferation and angiogenesis in vivo and in vitro. a Injection in the right armpit of MHCC-97H cells transfected with empty vector or MYLK-AS1 expression vector and shMYLK-AS1-NC or shMYLK-AS1–2 in the upper panel. Representative images of xenograft tumors are shown in the bottom panel. b-c Tumor weight and volume of the xenograft in MYLK-AS1 overexpression groups and control group or MYLK-AS1 knockdown group and control group. d Representative IHC staining results of CD34 in corresponding xenografts (scale bar = 50 μm). e-f Statistical analysis of the H-score of CD34 in the corresponding xenografts. Results are presented as mean ± SD from three independent experiments. g Cell proliferation of HUVECs cells cultured alone and co-cultured with MHCC-97H cells by CCK-8. h MYLK-AS1 knocked down or overexpressed or E2F7 overexpressed MHCC-97H cells co-cultured with HUVECs cells and consequent HUVEC proliferation by CCK-8. Results are expressed as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001