Table 3.
Pooled prevalence of post-Cryptosporidium sequelae estimated by a random effects model, according to clinical manifestation by time period post-infection
| Sequelae | No. of studies | Pooled estimate (%) (95% CI) |
Cochranʼs Q | P-value |
|---|---|---|---|---|
| < 6 months | ||||
| Diarrhoea | 5 | 43 (12–77) | 532.73 | < 0.001 |
| Abdominal pain | 5 | 41 (16–68) | 278.61 | < 0.001 |
| Loss of appetite | 4 | 26 (21–32) | 8.11 | 0.04 |
| Nausea | 3 | 37 (59–69) | 82.86 | < 0.001 |
| Fatigue | 5 | 39 (17–63) | 227.41 | < 0.001 |
| Weight loss | 4 | 22 (19–26) | 3.20 | 0.36 |
| Fever | 3 | 15 (2–33) | 37.77 | < 0.001 |
| Vomiting | 5 | 9 (3–16) | 47.83 | < 0.001 |
| Joint pain | 5 | 18 (15–21) | 5.75 | 0.22 |
| Headache | 5 | 21 (5–42) | 215.84 | < 0.001 |
| Dizzy spells | 4 | 9 (5–14) | 10.81 | 0.01 |
| Eye pain | 5 | 9 (4–15) | 35.88 | < 0.001 |
| Blurred vision | 3 | 5 (3–7) | 2.10 | 0.35 |
| Blood in stool | 3 | 4 (3–6) | 0.00 | 1 |
| > 6 months | ||||
| Diarrhoea | 8 | 16 (13–22) | 31.14 | < 0.001 |
| Abdominal pain | 8 | 16 (9–25) | 71.17 | < 0.001 |
| Loss of appetite | 5 | 14 (10–18) | 8.68 | 0.07 |
| Nausea | 5 | 18 (13–25) | 19.47 | < 0.001 |
| Fatigue | 8 | 16 (9–26) | 80.85 | < 0.001 |
| Weight loss | 5 | 6 (4–9) | 6.50 | 0.16 |
| Fever | 2 | 10 (3–21) | 2.57 | 0.11 |
| Vomiting | 5 | 7 (3–12) | 21.53 | < 0.001 |
| Joint pain | 8 | 14 (9–19) | 45.27 | < 0.001 |
| Headache | 5 | 22 (12–34) | 52.38 | < 0.001 |
| Dizzy spells | 2 | 6 (2–11) | 0.04 | 0.84 |
| Eye pain | 5 | 12 (7–14) | 8.84 | 0.07 |
| Blurred vision | 2 | 9 (4–14) | 0.01 | 0.94 |
| Blood in stool | 4 | 3 (0–6) | 11.78 | 0.01 |