Table 3.

Pharmacokinetic parameters of PTX in different formulations

Parameter	Units	PTX-Sol	Taxol	GA/PTX-NLC	RGE-GA/PTX-NLC	R9dGR-GA/PTX-NLC
AUC0→∞	μg/mL h	7.66 ± 0.79	22.58 ± 3.55**	16.66 ± 3.35**	17.65 ± 1.83**	13.53 ± 1.83*
t½	h	2.62 ± 0.20	2.16 ± 0.16	3.25 ± 0.45**	2.92 ± 0.03	3.48 ± 0.10**
CL	mL/h/kg	960.32 ± 100.05	328.26 ± 47.80***	451.69 ± 101.70***	416.52 ± 43.27***	546.34 ± 75.85***
MRT	h	1.88 ± 0.14	1.92 ± 0.04	2.23 ± 0.32	2.11 ± 0.02	2.43 ± 0.09*

*P < 0.05, **P < 0.01, ***P < 0.001 compared with PTX-Sol. Results are expressed as mean ± SD (n = 3)