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. 2020 Sep 4;18:123. doi: 10.1186/s12951-020-00681-8

Table 4.

Pharmacokinetic parameters of GA in different formulations

Parameter Units GA-Sol GA/PTX-NLC RGE-GA/PTX-NLC R9dGR-GA/PTX-NLC
AUC0→∞ μg/mL h 1.44 ± 0.23 2.56 ± 0.61 2.45 ± 0.57 3.10 ± 0.99*
h 2.70 ± 0.68 5.12 ± 0.75** 4.72 ± 0.60** 4.38 ± 0.33*
CL mL/h/kg 5647.32 ± 963.53 3248.17 ± 758.95** 3381.66 ± 772.54* 2754.72 ± 824.02**
MRT h 3.29 ± 0.24 4.54 ± 0.24** 4.37 ± 0.44** 5.14 ± 0.52***

*P < 0.05, **P < 0.01, ***P < 0.001 compared with GA-Sol. Results are expressed as mean ± SD (n = 3)