Table 1.

Representative chemicals produced by B. subtilis

Products	Strains	Characteristics	Titer	References
Riboflavin	B. subtilis 125	The deregulation of the rib operon and purine de novo synthesis pathway	4232 ± 34.42 mg/L	[50]
Menaquinone-7	B. subtilis 20-QT	Co-overexpression of tatAD-CD and qcrA-C	410 mg/L	[60]
Scyllo-Inositol	B. subtilis KU303	Deletion of iolABCDEF, iolHIJ, iolX and iolR, combined with the expression of IolG, IolW, IolT and PntAB	27.6 g/L	[61]
Hyaluronic acid	B. subtilis E168TH	Expression of hasA, tuaD, gtaB, glmU, glmM, glmS, and H6LHyal	19.38 g/ L	[64]
N-acetylglucosamine	B. subtilis 168 BNDR122	Deletion of nagP, gamP, gamA, gamR, nagA, nagB, ldh, alsRSD, pta, ackA, glcK, pckA, pyk, lacA and amyE, combined with the expression of GNAI	131.6 g/L	[67]
Amorphadiene	B. subtilis 1A1	Overexpression of dxs, idi and ads	20 mg/L	[96]
Poly-γ-glutamic acid	B. subtilis ZJU − 7	Optimizing culture conditions	101.1 g/L	[97]
Acetoin	B. subtilis CGMCC 13,141	Deletion of araR, bdhA and acoA	83.7 g/L	[98]
Shikimate	B. subtilis 168 CLC6-PYKA	Deletion of pykA and aroI	4.67 g/L	[99]
2,3-Butanediol	B. subtilis F9	Deletion of upp, acoA, bdhA, pta, and ldh, combined with the expression of alsS, alsD, budC, and udhA	103.7 g/L	[100]
Isobutanol	B. subtilis UL08	Deletion of alsS, ldh, pdhC and pgi, combined with the expression of zwf and udhA	6.12 g/L	[101]
Chondroitin	B. subtilis E168H	Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD	5.22 g /L	[102]
Heparosan	B. subtilis E168H	Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD	5.82 g/ L	[102]