Riboflavin |
B. subtilis 125 |
The deregulation of the rib operon and purine de novo synthesis pathway |
4232 ± 34.42 mg/L |
[50] |
Menaquinone-7 |
B. subtilis 20-QT |
Co-overexpression of tatAD-CD and qcrA-C
|
410 mg/L |
[60] |
Scyllo-Inositol |
B. subtilis KU303 |
Deletion of iolABCDEF, iolHIJ, iolX and iolR, combined with the expression of IolG, IolW, IolT and PntAB
|
27.6 g/L |
[61] |
Hyaluronic acid |
B. subtilis E168TH |
Expression of hasA, tuaD, gtaB, glmU, glmM, glmS, and H6LHyal
|
19.38 g/ L |
[64] |
N-acetylglucosamine |
B. subtilis 168 BNDR122 |
Deletion of nagP, gamP, gamA, gamR, nagA, nagB, ldh, alsRSD, pta, ackA, glcK, pckA, pyk, lacA and amyE, combined with the expression of GNAI
|
131.6 g/L |
[67] |
Amorphadiene |
B. subtilis 1A1 |
Overexpression of dxs, idi and ads
|
20 mg/L |
[96] |
Poly-γ-glutamic acid |
B. subtilis ZJU − 7 |
Optimizing culture conditions |
101.1 g/L |
[97] |
Acetoin |
B. subtilis CGMCC 13,141 |
Deletion of araR, bdhA and acoA
|
83.7 g/L |
[98] |
Shikimate |
B. subtilis 168 CLC6-PYKA |
Deletion of pykA and aroI
|
4.67 g/L |
[99] |
2,3-Butanediol |
B. subtilis F9 |
Deletion of upp, acoA, bdhA, pta, and ldh, combined with the expression of alsS, alsD, budC, and udhA
|
103.7 g/L |
[100] |
Isobutanol |
B. subtilis UL08 |
Deletion of alsS, ldh, pdhC and pgi, combined with the expression of zwf and udhA
|
6.12 g/L |
[101] |
Chondroitin |
B. subtilis E168H |
Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD
|
5.22 g /L |
[102] |
Heparosan |
B. subtilis E168H |
Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD
|
5.82 g/ L |
[102] |