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. 2020 Sep 4;8:154. doi: 10.1186/s40478-020-01001-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Soleus muscle of Hom mice at the ultrastructural level. a Longitudinal semithin section of Epon embedded soleus muscle of an adult Hom mouse stained with toluidine blue. Shown is a section with two neighboring darkly stained macrolesions (arrows). Note numerous elongated and swollen mitochondria (arrowheads). b Transmission electron microscopy of an ultrathin section similar to the section shown in A. Depicted are two macrolesions (arrows) surrounded by normally appearing myofibrils. Also, here many elongated and swollen mitochondria are observed (arrowheads). c A section containing three microlesions (arrows). The boxed microlesions are shown enlarged in panels d_i-d_iii. Bars: 5 μm (a, c), 10 μm (b), 2.5 μm (d_i-d_iii)